IAM Columns for Drug Discovery

Accelerate Drug Discovery using IAM Chromatography

  • Rapidly screen drug/phospholipid interactions
  • Identify suitable compounds early in the process
  • Identify and eliminate compounds with low permeability
  • Predict in vivo compound behavior, reducing need for animal studies

Immobilized Artificial Membrane (IAM) technology is an innovative approach to determining drug membrane permeability using a chromatographic column surface that emulates the lipid environment of the cell membrane. As phospholipids are major components of tissues and cells, drug interaction with phospholipids is an important contributor to distribution. IAM chromatography can be used to quickly measure drug/phospholipid interactions via retention times. Regis Technologies IAM Columns are high quality, long lasting HPLC columns providing reliable measurements across a wide range of drug molecules.

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Tools for Drug Discovery

IAM.PC.DD2

Estimate membrane permeability of small molecule drugs
Tools for Drug Discovery

IAM Drug Screen Calibration Mixture

Correlate drug retention factors
Tools for Drug Discovery

Fast-Screen Mini Column

Characterize large libraries of compounds with this rapid and economical screening method
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