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Approximately 30% of organic chemical pesticides are chiral molecules, and, since 2007 ~44% of new pesticidal molecules contain at least one asymmetric center (Jeschke, 2018). This is significant because, in some cases, only one stereoisomer is responsible for the targeted effects while the others are less active or entirely inactive. Differences in efficacy, toxicity, environmental effects, and degradation rates suggest the potential need for robust characterization and determination of enantiomeric ratios of pesticide products. Chiral chromatography provides both a way to determine these ratios and, if desired, a means to prepare enriched product with better specificity and/or lower toxicity. In this study, high-performance liquid chromatography (HPLC) chiral separations of 20 agrochemical compounds were performed by screening compounds on each of seven chiral stationary phases (CSPs) with each of two different mobile phases. “Hit” rates, determined by resolution values (Rs) ≥ 1, are reported for each column/mobile phase combination. The instances of highest resolution along with the number of unique hits are also reported for each column. Download |