As the number and complexity of chiral drugs and biologically active compounds increases, there is a growing need to advance chiral separation techniques. The number one way to separate chiral compounds is with HPLC using chiral stationary phases. This editorial web seminar presented by Zachary S. Breitbach of AbbVie, will address the need for improved chiral separations and discuss approaches for screening chiral columns, as well as new advancements in chiral column technology that lead to high efficiency and ultrafast chiral separations.